TMEM63B

Across TCGA pan-cancer cohorts, TMEM63B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM63B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM63B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM63B is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where TMEM63B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM63B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.138	<.001	12	view →
KIRC	Female	All	+0.845	<.001	12	view →
KIRP	Female	II,III,IV	+0.839	.001	9	view →
THCA	Male	All	+0.786	<.001	9	view →
BRCA	All	III,IV	+1.278	<.001	8	view →
LUAD	Male	All	−0.909	<.001	8	view →
KICH	All	All	−0.741	<.001	7	view →
LIHC	All	All	+0.641	<.001	7	view →
UCEC	All	III,IV	+1.548	<.001	6	view →
STAD	Male	II,III,IV	+1.031	<.001	5	view →
LUSC	Male	II,III,IV	−0.794	<.001	5	view →
COAD	All	All	−0.403	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM63B–HNSC

Open the HNSC breakdown →