TMEM63B

Across TCGA patient cohorts, TMEM63B mutation is significantly associated with the RNA expression of many other genes, with 3,144 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM63B-associated genes across cancer lineages are RASSF1, RPS27L, and PIGN. Each is linked with TMEM63B in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM63B-to-partner and partner-to-TMEM63B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASSF1 grouped by TMEM63B-low versus TMEM63B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63B→partner) and Y-score (partner→TMEM63B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RASSF1 →	+0.600	+2.732	<.001	.003	3	4
UCEC	RPS27L →	+0.608	+3.928	<.001	<.001	3	3
COAD	PIGN →	+0.529	+3.389	<.001	.004	3	3
UCEC	ATP6V1D →	+0.423	+3.087	<.001	<.001	3	3
UCEC	KIAA0586 →	+0.328	+3.064	.001	<.001	3	3
COAD	CEP76 →	+0.434	+2.933	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,144 associations by consensus.

RASSF1 by TMEM63B expression — SKCM

Explore this box plot interactively →