TMEM63B

Across TCGA patient cohorts, TMEM63B mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM63B-associated genes across cancer lineages are Caspase-7-cleavedD198, Lck, and MSH6. Each is linked with TMEM63B in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM63B-to-partner and partner-to-TMEM63B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TMEM63B-low versus TMEM63B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63B→partner) and Y-score (partner→TMEM63B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.905	+2.807	<.001	.002	3	3
UCEC	Lck →	+0.218	+2.700	.002	.006	3	2
UCEC	MSH6 →	-0.456	-2.700	<.001	.005	3	2
UCEC	ATM →	-0.709	-3.687	<.001	.001	3	2
COAD	RAD51 →	+0.134	+2.467	.049	.011	3	2
UCEC	eEF2 →	+0.284	+1.584	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by TMEM63B expression — UCEC

Explore this box plot interactively →