TMEM63B

Across TCGA cell cohorts, TMEM63B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,845 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM63B-associated GO terms across cancer lineages are Intestinal stem cell homeostasis, Surfactant homeostasis, and Cytosolic transport. Each is linked with TMEM63B in more than 15 cancer types. Because this analysis shows association rather than direction, both TMEM63B-to-partner and partner-to-TMEM63B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intestinal stem cell homeostasis grouped by TMEM63B-low versus TMEM63B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63B→partner) and Y-score (partner→TMEM63B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Intestinal stem cell homeostasis →	+0.227	+1.017	<.001	<.001	3	16
KIDNEY	Surfactant homeostasis →	+0.293	+1.126	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.081	+1.125	<.001	<.001	3	12
LARGE_INTESTINE	Regulation of protein catabolic process in the vacuole →	+0.142	+0.852	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Glycerolipid biosynthetic process →	+0.045	+0.944	.003	<.001	3	12
OVARY	Vacuole organization →	+0.045	+0.614	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,845 associations by consensus.

Intestinal stem cell homeostasis by TMEM63B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →