TMEM63B

Across TCGA cell cohorts, TMEM63B mutation is significantly associated with the RNA expression of many other genes, with 402 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM63B-associated genes across cancer lineages are STMND1, IFNA21, and OR2V1. Each is linked with TMEM63B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM63B-to-partner and partner-to-TMEM63B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STMND1 grouped by TMEM63B-low versus TMEM63B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63B→partner) and Y-score (partner→TMEM63B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STMND1 →	+0.316	+3.451	.003	.002	3	2
BLOOD_Myeloma	IFNA21 →	+0.079	+3.716	<.001	.005	3	1
BLOOD_Myeloma	OR2V1 →	+0.027	+3.285	<.001	.009	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
PANCREAS	PRSS58 →	+0.067	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	CBY1 →	+0.781	+3.330	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 402 associations by consensus.

STMND1 by TMEM63B expression — LARGE_INTESTINE

Explore this box plot interactively →