Across TCGA pan-cancer cohorts, TMEM63A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM63A data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM63A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM63A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC and ACC are the cancer types where TMEM63A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.620	.008	28	view →
ACC	OS	Median	II,III,IV	0.273	0.766	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TMEM63A tumor-vs-normal RNA expression · all TMEM63A data types