Across TCGA patient cohorts, TMEM63A mutation is significantly associated with the RNA expression of many other genes, with 1,851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM63A-associated genes across cancer lineages are MIR8076, RPL32P36, and RPS17P7. Each is linked with TMEM63A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM63A-to-partner and partner-to-TMEM63A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63A→partner) and Y-score (partner→TMEM63A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR8076 →	+0.235	+3.699	<.001	.003	3	2
COAD	RPL32P36 →	+0.365	+3.917	<.001	.007	3	2
COAD	RPS17P7 →	+0.268	+5.187	<.001	<.001	3	2
COAD	MTND4LP2 →	+0.228	+5.136	<.001	.002	3	2
COAD	IGHVII-74-1 →	+0.556	+5.332	<.001	.002	3	2
BRCA	OR10W1 →	+0.053	+5.509	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,851 associations by consensus.

Exploration

TMEM63A survival (RNA) · tumor vs normal (RNA) · all TMEM63A data types