TMEM63A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TMEM63A mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM63A-associated genes across cancer lineages are Notch1, eIF4E, and JNK_pT183_Y185. Each is linked with TMEM63A in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM63A-to-partner and partner-to-TMEM63A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63A→partner) and Y-score (partner→TMEM63A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNotch1 →+0.168+1.502.001.03033
UCECeIF4E →+0.185+2.472.016.01032
UCECJNK_pT183_Y185 →-0.163-1.834.008.00832
UCECAnnexin_VII →-0.102-1.502.046.03032
UCECSTAT3_pY705 →-0.294-2.311.002.00532
UCEC14-3-3_beta →-0.121-3.780.001<.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration