Across TCGA cell cohorts, TMEM63A mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM63A-associated genes across cancer lineages are KRTAP11-1, NXNL1, and OR9I1. Each is linked with TMEM63A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM63A-to-partner and partner-to-TMEM63A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63A→partner) and Y-score (partner→TMEM63A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP11-1 →	+0.022	+5.415	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	NXNL1 →	+0.023	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	OR9I1 →	+0.012	+4.736	<.001	.009	3	1
BLOOD_Leukemia	SLC32A1 →	+0.596	+3.034	<.001	.004	3	1
BLOOD_Leukemia	OR11H1 →	+0.051	+3.464	<.001	.003	3	1
BLOOD_Leukemia	TRPC6 →	+0.485	+3.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

TMEM63A survival (RNA) · tumor vs normal (RNA) · all TMEM63A data types