TMEM62

Across TCGA patient cohorts, TMEM62 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM62-associated genes across cancer lineages are Caspase-8, 14-3-3_beta, and EGFR_pY1068. Each is linked with TMEM62 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM62-to-partner and partner-to-TMEM62 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by TMEM62-low versus TMEM62-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM62→partner) and Y-score (partner→TMEM62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.266	-3.880	.004	<.001	3	2
UCEC	14-3-3_beta →	-0.081	-3.143	.032	.018	3	1
UCEC	EGFR_pY1068 →	-0.197	-1.700	.036	.042	3	1
UCEC	A-Raf_pS299 →	-0.130	-3.321	.003	.009	3	1
UCEC	IGFBP2 →	-0.690	-2.459	.004	.019	3	1
UCEC	JNK2 →	+0.281	+3.486	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Caspase-8 by TMEM62 expression — UCEC

Explore this box plot interactively →