TMEM62

Across TCGA pan-cancer cohorts, TMEM62 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM62’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM62 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM62 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KICH, BLCA, and LUAD are the cancer types where TMEM62 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM62 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.831	<.001	10	view →
BLCA	All	All	+0.580	.001	10	view →
LUAD	Male	II,III,IV	+1.139	<.001	9	view →
LIHC	Male	III,IV	+0.980	<.001	9	view →
STAD	Male	III,IV	+1.586	<.001	8	view →
BRCA	All	All	+0.499	<.001	6	view →
THCA	All	All	+0.140	.005	6	view →
CHOL	Male	All	+2.340	<.001	5	view →
ESCA	All	All	+1.004	.009	4	view →
COAD	Male	All	+0.561	.001	4	view →
READ	All	II,III,IV	+0.732	.007	3	view →
UCEC	All	All	+0.508	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM62–KICH

Open the KICH breakdown →