TMEM62

Across TCGA cell cohorts, TMEM62 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM62-associated genes across cancer lineages are NKX6-3, MMD2, and UTF1. Each is linked with TMEM62 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM62-to-partner and partner-to-TMEM62 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX6-3 grouped by TMEM62-low versus TMEM62-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM62→partner) and Y-score (partner→TMEM62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NKX6-3 →	+0.030	+3.930	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.226	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.013	+5.357	<.001	.003	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	CARD18 →	+0.261	+3.347	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NKX6-3 by TMEM62 expression — SKIN

Explore this box plot interactively →