TMEM53

Across TCGA patient cohorts, TMEM53 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,931 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TMEM53-associated proteins across cancer lineages are DLG3, SCP2, and ICA1. Each is linked with TMEM53 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM53-to-partner and partner-to-TMEM53 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM53 versus DLG3 in LUAD, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM53→partner) and Y-score (partner→TMEM53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DLG3 →	+0.349	+0.367	<.001	.001	3	4
PDAC	SCP2 →	+0.410	+0.540	<.001	<.001	3	4
LSCC	ICA1 →	+0.489	+0.394	<.001	<.001	3	4
LUAD	ZMPSTE24 →	+0.378	+0.305	<.001	.002	3	3
LSCC	UBR4 →	+0.165	+0.322	.001	.002	3	3
OV	PPCS →	+0.516	+0.453	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,931 associations by consensus.

TMEM53 vs DLG3 — LUAD

Explore this scatter interactively →