TMEM53

Across TCGA pan-cancer cohorts, TMEM53 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TMEM53 data layer compared with 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TMEM53 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM53 expression acts as an unfavorable survival marker, although some lineages such as UVM and ACC show a favorable association.

LUSC, UVM, and LGG are the cancer types where TMEM53 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.602	0.802	.001	53	view →
UVM	DFS	Tertile	All	0.774	0.436	.002	53	view →
LGG	DFS	Median	All	0.294	0.502	<.001	53	view →
UCS	DFS	Median	III,IV	0.258	0.582	.002	36	view →
KIRC	DFS	Tertile	IV	0.220	0.509	.010	31	view →
ESCA	OS	Median	All	0.617	1.000	.009	16	view →
ACC	DFS	Tertile	III,IV	0.559	0.093	.002	15	view →
LUAD	OS	Tertile	All	0.533	0.351	.007	15	view →
OV	OS	Median	II,III,IV	0.876	0.807	.023	14	view →
STAD	OS	Quartile	All	0.772	0.561	.004	13	view →
DLBC	DFS	Tertile	III,IV	0.984	0.143	.003	12	view →
KICH	DFS	Median	II,III,IV	0.679	1.000	.022	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TMEM53–LUSC (DFS)

Open the LUSC breakdown →