TMEM53

Across TCGA patient cohorts, TMEM53 mutation is significantly associated with the RNA expression of many other genes, with 900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM53-associated genes across cancer lineages are SNORD116-5, RNU6-1155P, and RNY1P1. Each is linked with TMEM53 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM53-to-partner and partner-to-TMEM53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-5 grouped by TMEM53-low versus TMEM53-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM53→partner) and Y-score (partner→TMEM53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD116-5 →	+0.289	+4.452	<.001	<.001	3	2
UCEC	RNU6-1155P →	+0.122	+4.475	.002	.003	3	2
UCEC	RNY1P1 →	+0.214	+3.461	<.001	.003	3	2
UCEC	RNU2-47P →	+0.106	+4.475	<.001	.003	3	2
UCEC	RN7SKP181 →	+0.137	+2.811	<.001	.004	3	2
UCEC	TDGF1P1 →	+0.082	+3.572	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 900 associations by consensus.

SNORD116-5 by TMEM53 expression — SKCM

Explore this box plot interactively →