TMEM53

Across TCGA patient cohorts, TMEM53 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM53-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and Src_pY416. Each is linked with TMEM53 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM53-to-partner and partner-to-TMEM53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TMEM53-low versus TMEM53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM53→partner) and Y-score (partner→TMEM53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.235	-3.571	.003	.002	3	2
UCEC	Notch1 →	+0.248	+3.584	<.001	.002	3	2
UCEC	Src_pY416 →	-0.286	-3.321	.014	.010	3	2
UCEC	eEF2 →	+0.534	+3.584	.001	.002	3	1
UCEC	FoxM1 →	+0.385	+3.584	.002	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.198	-3.312	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

JNK_pT183_Y185 by TMEM53 expression — UCEC

Explore this box plot interactively →