TMEM53

Across TCGA cell cohorts, TMEM53 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,383 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM53-associated GO terms across cancer lineages are Glycerolipid biosynthetic process, Phospholipid biosynthetic process, and Monocarboxylic acid catabolic process. Each is linked with TMEM53 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM53-to-partner and partner-to-TMEM53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerolipid biosynthetic process grouped by TMEM53-low versus TMEM53-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM53→partner) and Y-score (partner→TMEM53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Glycerolipid biosynthetic process →	+0.044	+0.912	<.001	<.001	3	11
OVARY	Phospholipid biosynthetic process →	+0.035	+0.648	.002	.001	2	12
STOMACH	Monocarboxylic acid catabolic process →	+0.074	+0.771	.002	.003	2	11
STOMACH	Fatty acid catabolic process →	+0.084	+0.989	.001	<.001	2	11
BLOOD_Lymphoma	Positive regulation of autophagy →	+0.039	+0.919	<.001	<.001	3	10
LUNG_SCLC	Negative regulation of protein-containing complex assembly →	+0.060	+0.966	.007	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,383 associations by consensus.

Glycerolipid biosynthetic process by TMEM53 expression — PANCREAS

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