TMEM53

Across TCGA cell cohorts, TMEM53 mutation is significantly associated with the drug of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM53-associated genes across cancer lineages are Mirin, GSK1904529A, and AZD5438. Each is linked with TMEM53 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM53-to-partner and partner-to-TMEM53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by TMEM53-low versus TMEM53-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM53→partner) and Y-score (partner→TMEM53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.482	+2.646	.010	.047	3	1
LARGE_INTESTINE	GSK1904529A →	+0.601	+2.700	<.001	.030	3	1
LARGE_INTESTINE	AZD5438 →	+0.552	+2.777	.024	.038	3	1
LARGE_INTESTINE	LCL161 →	+0.330	+2.646	.044	.047	3	1
LARGE_INTESTINE	GSK2801 →	+0.350	+2.649	.027	.046	3	1
LARGE_INTESTINE	Bromosporine →	+0.362	+2.649	.035	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Mirin by TMEM53 expression — LARGE_INTESTINE

Explore this box plot interactively →