TMEM52B

Across TCGA cell cohorts, TMEM52B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,374 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM52B-associated GO terms across cancer lineages are Negative regulation of oxidoreductase activity, Regulation of cytokine-mediated signaling pathway, and Regulation of modification of postsynaptic actin cytoskeleton. Each is linked with TMEM52B in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM52B-to-partner and partner-to-TMEM52B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of oxidoreductase activity grouped by TMEM52B-low versus TMEM52B-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM52B→partner) and Y-score (partner→TMEM52B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of oxidoreductase activity →	+0.117	+1.326	.001	.001	3	6
OESOPHAGUS	Regulation of cytokine-mediated signaling pathway →	+0.101	+2.644	<.001	<.001	3	6
STOMACH	Regulation of modification of postsynaptic actin cytoskeleton →	+0.206	+2.282	.003	.005	3	6
LARGE_INTESTINE	Regulation of amyloid fibril formation →	+0.095	+1.291	<.001	.008	3	6
LUNG_NSCLC_LUAD	Ganglion development →	-0.116	-0.831	.001	.009	3	6
BLOOD_Leukemia	Positive regulation of cell maturation →	-0.101	-0.478	.008	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,374 associations by consensus.

Negative regulation of oxidoreductase activity by TMEM52B expression — OVARY

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