TMEM52B

Across TCGA pan-cancer cohorts, TMEM52B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM52B data layer compared with 4 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TMEM52B RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM52B expression acts as an unfavorable survival marker, although some lineages such as SKCM and KICH show a favorable association.

SKCM, KICH, and LGG are the cancer types where TMEM52B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.409	0.257	<.001	79	view →
KICH	DFS	Median	All	1.000	0.783	.002	51	view →
LGG	DFS	Tertile	All	0.645	0.793	<.001	38	view →
ACC	OS	Median	II,III,IV	0.765	0.933	.009	17	view →
STAD	OS	Tertile	IV	0.208	0.711	.024	15	view →
LIHC	DFS	Median	All	0.404	0.631	.001	12	view →
GBM	DFS	Tertile	All	0.170	0.290	.007	11	view →
HNSC	OS	Tertile	II,III,IV	0.663	0.773	.006	11	view →
BLCA	DFS	Median	IV	0.308	0.631	.007	10	view →
TGCT	DFS	Median	All	0.750	0.913	.022	10	view →
MESO	OS	Median	III,IV	0.302	0.712	.017	9	view →
LUAD	OS	Tertile	All	0.868	0.786	.020	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM52B–SKCM (OS)

Open the SKCM breakdown →