TMEM51-AS1

Across TCGA pan-cancer cohorts, TMEM51-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TMEM51-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TMEM51-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM51-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and SKCM show a favorable association.

KIRP, THCA, and SKCM are the cancer types where TMEM51-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.957	0.860	.002	71	view →
THCA	DFS	Tertile	All	0.783	0.909	.002	63	view →
SKCM	DFS	Tertile	All	0.690	0.539	<.001	50	view →
LGG	OS	Median	All	0.749	0.866	<.001	42	view →
BLCA	OS	Quartile	All	0.842	0.644	.001	38	view →
DLBC	DFS	Median	III,IV	0.984	0.294	.003	33	view →
ESCA	OS	Median	All	0.418	1.000	.005	18	view →
LUAD	DFS	Median	III,IV	0.330	0.589	.038	12	view →
THYM	OS	Median	All	0.916	1.000	.007	11	view →
KIRC	OS	Median	All	0.917	0.841	.012	9	view →
MESO	DFS	Median	II,III,IV	0.309	0.591	.020	9	view →
COAD	OS	Quartile	All	0.479	0.800	.009	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TMEM51-AS1–KIRP (DFS)

Open the KIRP breakdown →