TMEM50B

Across TCGA patient cohorts, TMEM50B mutation is significantly associated with the RNA expression of many other genes, with 174 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM50B-associated genes across cancer lineages are NIPA2P3, PTPRN2, and CXCL13. Each is linked with TMEM50B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM50B-to-partner and partner-to-TMEM50B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPA2P3 grouped by TMEM50B-low versus TMEM50B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM50B→partner) and Y-score (partner→TMEM50B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NIPA2P3 →	+0.029	+7.640	<.001	.009	3	1
UCEC	PTPRN2 →	+0.573	+3.593	.009	.001	3	1
UCEC	CXCL13 →	+1.809	+2.700	.001	.006	3	1
UCEC	TOMM40L →	-0.778	-3.427	.003	.005	3	1
UCEC	SLAMF6 →	+0.812	+3.459	.002	.005	3	1
UCEC	CXCL5 →	-1.617	-3.796	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 174 associations by consensus.

NIPA2P3 by TMEM50B expression — BLCA

Explore this box plot interactively →