TMEM50B

Across TCGA pan-cancer cohorts, TMEM50B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TMEM50B data layer compared with 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TMEM50B RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM50B expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, STAD, and LGG are the cancer types where TMEM50B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.763	0.608	<.001	110	view →
STAD	OS	Median	IV	0.241	0.783	<.001	81	view →
LGG	DFS	Median	All	0.653	0.824	<.001	50	view →
UVM	DFS	Tertile	III,IV	0.253	0.815	.002	44	view →
ACC	DFS	Quartile	All	0.210	0.759	<.001	40	view →
HNSC	DFS	Median	All	0.700	0.554	<.001	40	view →
KIRC	DFS	Quartile	All	0.917	0.688	<.001	31	view →
LIHC	DFS	Median	All	0.471	0.608	<.001	30	view →
MESO	DFS	Median	III,IV	0.222	0.616	.008	15	view →
LAML	DFS	Tertile	All	0.502	0.267	.024	14	view →
SKCM	OS	Quartile	All	0.385	0.270	.007	13	view →
THCA	DFS	Median	All	0.893	0.791	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

TMEM50B–LUAD (OS)

Open the LUAD breakdown →