TMEM50B

Across TCGA patient cohorts, TMEM50B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM50B-associated genes across cancer lineages are Notch1, p62 Lck ligand, and S6_pS240_S244. Each is linked with TMEM50B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM50B-to-partner and partner-to-TMEM50B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TMEM50B-low versus TMEM50B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM50B→partner) and Y-score (partner→TMEM50B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.153	+2.820	.024	.035	3	1
UCEC	p62 Lck ligand →	+0.454	+3.179	.003	.010	3	1
UCEC	S6_pS240_S244 →	+0.520	+3.013	.008	.018	3	1
UCEC	ATM →	-0.495	-2.459	.024	.020	3	1
UCEC	Caspase-8 →	-0.257	-3.143	.034	.018	3	1
UCEC	c-Kit →	-0.234	-2.986	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by TMEM50B expression — UCEC

Explore this box plot interactively →