Across TCGA pan-cancer cohorts, TMEM50A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM50A data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TMEM50A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM50A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, BLCA, and READ are the cancer types where TMEM50A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.586	0.875	<.001	29	view →
BLCA	OS	Median	III,IV	0.141	0.655	.002	27	view →
READ	DFS	Median	II,III,IV	0.112	0.800	.002	6	view →
UCEC	DFS	Median	All	1.000	0.625	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TMEM50A tumor-vs-normal RNA expression · all TMEM50A data types