Across TCGA pan-cancer cohorts, TMEM50A RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM50A’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM50A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM50A is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.
HNSC, KICH, and BLCA are the cancer types where TMEM50A tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM50A RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.