Across TCGA patient cohorts, TMEM50A mutation is significantly associated with the RNA expression of many other genes, with 841 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM50A-associated genes across cancer lineages are RNU6-73P, LIN7C, and CAPN5. Each is linked with TMEM50A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM50A-to-partner and partner-to-TMEM50A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM50A→partner) and Y-score (partner→TMEM50A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-73P →	+0.144	+3.003	.007	.007	3	2
UCEC	LIN7C →	+0.628	+2.928	.002	.001	3	1
UCEC	CAPN5 →	-0.806	-3.791	.001	<.001	3	1
UCEC	FRG1BP →	+0.863	+3.330	.003	.005	3	1
UCEC	EI24 →	+0.481	+3.212	.006	.009	3	1
UCEC	TIRAP →	+0.464	+2.254	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 841 associations by consensus.

Exploration

TMEM50A survival (RNA) · tumor vs normal (RNA) · all TMEM50A data types