TMEM47

Across TCGA cell cohorts, TMEM47 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM47-associated genes across cancer lineages are HTN1, OR14K1, and TRIM64B. Each is linked with TMEM47 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM47-to-partner and partner-to-TMEM47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTN1 grouped by TMEM47-low versus TMEM47-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM47→partner) and Y-score (partner→TMEM47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HTN1 →	+0.379	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR14K1 →	+0.102	+5.022	<.001	.002	3	1
LARGE_INTESTINE	TRIM64B →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MS4A18 →	+0.028	+4.095	<.001	.009	3	1
LARGE_INTESTINE	KRTAP7-1 →	+0.060	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

HTN1 by TMEM47 expression — LARGE_INTESTINE

Explore this box plot interactively →