TMEM45B

Across TCGA patient cohorts, TMEM45B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM45B-associated genes across cancer lineages are Ku80, MEK1, and Paxillin. Each is linked with TMEM45B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM45B-to-partner and partner-to-TMEM45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TMEM45B-low versus TMEM45B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM45B→partner) and Y-score (partner→TMEM45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.300	+2.179	.008	.034	3	1
UCEC	MEK1 →	+0.485	+3.459	.006	.005	3	1
UCEC	Paxillin →	+0.291	+2.459	.020	.020	3	1
UCEC	PKC-a_pS657 →	+0.381	+2.472	.039	.011	3	1
UCEC	Rab11 →	-0.209	-3.584	.002	.002	3	1
UCEC	Src_pY416 →	-0.330	-3.571	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Ku80 by TMEM45B expression — UCEC

Explore this box plot interactively →