TMEM45B

Across TCGA pan-cancer cohorts, TMEM45B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TMEM45B data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TMEM45B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM45B expression acts as an unfavorable survival marker, although some lineages such as OV and READ show a favorable association.

KIRP, ACC, and OV are the cancer types where TMEM45B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.855	0.984	<.001	153	view →
ACC	DFS	Median	All	0.226	0.667	<.001	127	view →
OV	OS	Quartile	All	0.917	0.813	.002	42	view →
READ	DFS	Tertile	All	0.755	0.365	.006	38	view →
ESCA	OS	Median	All	0.617	1.000	.009	24	view →
LUSC	DFS	Median	All	0.584	0.695	.008	21	view →
BLCA	DFS	Quartile	IV	0.403	0.619	.018	10	view →
GBM	OS	Quartile	All	0.483	0.330	.010	9	view →
KICH	OS	Median	II,III,IV	0.652	0.925	.017	8	view →
LUAD	DFS	Tertile	III,IV	0.745	0.591	.031	8	view →
TGCT	DFS	Tertile	All	0.728	0.899	.022	6	view →
SKCM	DFS	Median	III,IV	0.185	0.435	.005	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TMEM45B–KIRP (OS)

Open the KIRP breakdown →