TMEM45B

Across TCGA cell cohorts, TMEM45B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,301 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEM45B-associated GO terms across cancer lineages are Serotonin secretion, Serotonin production involved in inflammatory response, and Serotonin secretion involved in inflammatory response. Each is linked with TMEM45B in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM45B-to-partner and partner-to-TMEM45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonin secretion grouped by TMEM45B-low versus TMEM45B-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM45B→partner) and Y-score (partner→TMEM45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Serotonin secretion →	+1.543	+3.143	<.001	.006	3	11
URINARY_TRACT	Serotonin production involved in inflammatory response →	+1.543	+3.143	<.001	.006	3	11
URINARY_TRACT	Serotonin secretion involved in inflammatory response →	+1.543	+3.143	<.001	.006	3	11
LUNG_NSCLC_LUSC	Cellular response to alcohol →	+0.143	+4.782	.003	<.001	3	10
URINARY_TRACT	Regulation of action potential →	+0.143	+2.813	<.001	.003	3	10
STOMACH	Regulation of hippocampal neuron apoptotic process →	+1.309	+2.691	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,301 associations by consensus.

Serotonin secretion by TMEM45B expression — URINARY_TRACT

Explore this box plot interactively →