TMEM45B

Across TCGA cell cohorts, TMEM45B mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM45B-associated genes across cancer lineages are RBMY1J and ACER1. Each is linked with TMEM45B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM45B-to-partner and partner-to-TMEM45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1J grouped by TMEM45B-low versus TMEM45B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM45B→partner) and Y-score (partner→TMEM45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	ACER1 →	+0.098	+3.823	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

RBMY1J by TMEM45B expression — SKIN

Explore this box plot interactively →