TMEM44

Across TCGA pan-cancer cohorts, TMEM44 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM44 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TMEM44 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM44 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

UVM, SARC, and UCEC are the cancer types where TMEM44 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.141	0.745	.011	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	OS	Median	III,IV	0.248	0.683	.042	3	view →
STAD	OS	Median	II,III,IV	1.000	0.397	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM44–UVM (DFS)

Open the UVM breakdown →