TMEM44

Across TCGA pan-cancer cohorts, TMEM44 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM44’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM44 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM44 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where TMEM44 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM44 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.643	<.001	12	view →
KIRC	Male	All	+1.555	<.001	12	view →
THCA	Male	All	+0.765	<.001	10	view →
KIRP	All	III,IV	+1.230	<.001	9	view →
LIHC	Female	II,III,IV	+1.088	<.001	8	view →
BLCA	All	All	+1.041	<.001	8	view →
STAD	Male	II,III,IV	+1.129	<.001	6	view →
KICH	Female	All	−1.698	<.001	5	view →
LUSC	All	All	+0.710	<.001	5	view →
ESCA	All	II,III,IV	+1.449	.016	4	view →
CHOL	Male	All	+2.823	<.001	3	view →
PAAD	All	All	+0.712	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM44–HNSC

Open the HNSC breakdown →