TMEM43

Across TCGA patient cohorts, TMEM43 mutation is significantly associated with the RNA expression of many other genes, with 1,051 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM43-associated genes across cancer lineages are RNA5SP325, LINC00265-2P, and PITHD1. Each is linked with TMEM43 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM43-to-partner and partner-to-TMEM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP325 grouped by TMEM43-low versus TMEM43-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM43→partner) and Y-score (partner→TMEM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP325 →	+0.169	+4.837	<.001	.003	3	3
UCEC	LINC00265-2P →	+0.061	+2.894	<.001	.001	3	2
UCEC	PITHD1 →	+0.379	+3.524	.007	.002	3	2
COAD	RNU6-1127P →	+0.644	+6.721	<.001	<.001	3	1
COAD	RNU6-1158P →	+0.413	+5.080	.008	.008	3	1
COAD	SDC4P →	+0.144	+5.283	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,051 associations by consensus.

RNA5SP325 by TMEM43 expression — CESC

Explore this box plot interactively →