TMEM39B

Across TCGA patient cohorts, TMEM39B mutation is significantly associated with the RNA expression of many other genes, with 1,820 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM39B-associated genes across cancer lineages are RBMY1A1, TRAJ12, and RN7SL654P. Each is linked with TMEM39B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM39B-to-partner and partner-to-TMEM39B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1A1 grouped by TMEM39B-low versus TMEM39B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM39B→partner) and Y-score (partner→TMEM39B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RBMY1A1 →	+0.352	+4.970	<.001	.005	3	2
UCEC	TRAJ12 →	+0.748	+2.581	<.001	<.001	3	2
UCEC	RN7SL654P →	+0.110	+2.694	.001	.004	3	2
UCEC	NCOA4P1 →	+0.068	+2.239	<.001	<.001	3	2
COAD	RN7SKP169 →	+0.209	+5.392	<.001	.002	3	2
COAD	MRPS18BP2 →	+0.326	+4.266	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,820 associations by consensus.

RBMY1A1 by TMEM39B expression — SKCM

Explore this box plot interactively →