TMEM38B

Across TCGA pan-cancer cohorts, TMEM38B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM38B data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TMEM38B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM38B expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

SKCM, UCEC, and LUAD are the cancer types where TMEM38B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.215	0.760	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.891	.032	8	view →
LUAD	DFS	Median	All	1.000	0.331	.015	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM38B–SKCM (DFS)

Open the SKCM breakdown →