TMEM38B

Across TCGA patient cohorts, TMEM38B mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM38B-associated genes across cancer lineages are Notch1, ATM, and 4E-BP1. Each is linked with TMEM38B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM38B-to-partner and partner-to-TMEM38B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TMEM38B-low versus TMEM38B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM38B→partner) and Y-score (partner→TMEM38B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.119	+1.887	.024	.029	3	2
UCEC	ATM →	-0.519	-2.000	.002	.030	3	2
UCEC	4E-BP1 →	+0.236	+1.904	.020	.029	3	2
UCEC	Cyclin-B1 →	+0.577	+2.169	.006	.003	3	2
UCEC	eIF4E →	+0.219	+3.472	.005	.002	3	1
UCEC	JNK2 →	+0.294	+2.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by TMEM38B expression — UCEC

Explore this box plot interactively →