TMEM37

Across TCGA patient cohorts, TMEM37 mutation is significantly associated with the RNA expression of many other genes, with 192 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM37-associated genes across cancer lineages are LINC01283, RNU6-198P, and RNU4-79P. Each is linked with TMEM37 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM37-to-partner and partner-to-TMEM37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01283 grouped by TMEM37-low versus TMEM37-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM37→partner) and Y-score (partner→TMEM37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01283 →	+0.279	+3.491	<.001	.002	3	2
SKCM	RNU6-198P →	+0.166	+4.039	<.001	.001	3	2
BLCA	RNU4-79P →	+0.208	+7.640	<.001	.009	3	2
BLCA	SNORD114-29 →	+0.373	+7.640	<.001	.009	3	2
COAD	TRAJ40 →	+1.996	+4.792	<.001	.003	3	2
COAD	LINC00906 →	+0.068	+4.237	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 192 associations by consensus.

LINC01283 by TMEM37 expression — SKCM

Explore this box plot interactively →