TMEM37

Across TCGA pan-cancer cohorts, TMEM37 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM37’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM37 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM37 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LUAD are the cancer types where TMEM37 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM37 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−5.583	<.001	11	view →
COAD	Female	All	−3.309	<.001	11	view →
LUAD	Female	III,IV	−1.668	<.001	11	view →
KIRP	Male	All	−1.680	<.001	9	view →
BRCA	All	II,III,IV	−2.251	<.001	8	view →
LUSC	Male	All	−0.778	<.001	5	view →
READ	All	All	−1.751	.006	4	view →
BLCA	Female	All	+1.611	.017	3	view →
KIRC	Female	All	+0.530	.008	3	view →
UCEC	All	All	+1.283	.001	2	view →
PRAD	All	All	−1.193	<.001	2	view →
THCA	All	IV	−1.130	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM37–KICH

Open the KICH breakdown →