TMEM35B

Across TCGA patient cohorts, TMEM35B RNA expression is significantly associated with the go_rna of many other GO terms, with 7,169 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible TMEM35B-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, MDA-5 signaling pathway, and Cap-dependent translational initiation. Each is linked with TMEM35B in more than 26 cancer types. Because this analysis shows association rather than direction, both TMEM35B-to-partner and partner-to-TMEM35B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by TMEM35B-low versus TMEM35B-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM35B→partner) and Y-score (partner→TMEM35B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Cytoplasmic pattern recognition receptor signaling pathway →	+0.060	+0.497	<.001	<.001	3	27
SCLC	MDA-5 signaling pathway →	+0.183	+0.760	<.001	<.001	3	27
DLBC	Cap-dependent translational initiation →	+0.086	+0.698	<.001	<.001	3	25
SCLC	Positive regulation of B cell proliferation →	+0.071	+0.490	<.001	<.001	3	25
DLBC	Positive regulation of translation in response to endoplasmic reticulum stress →	+0.094	+0.751	<.001	<.001	3	25
SCLC	Regulation of protein K48-linked ubiquitination →	+0.087	+0.592	.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,169 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by TMEM35B expression — SCLC

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