TMEM35B

Across TCGA pan-cancer cohorts, TMEM35B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TMEM35B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM35B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM35B is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KICH, and LUAD are the cancer types where TMEM35B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM35B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.036	<.001	12	view →
KICH	Female	II,III,IV	−2.418	<.001	10	view →
LUAD	All	III,IV	−0.737	<.001	9	view →
LUSC	Male	III,IV	−1.519	<.001	8	view →
LIHC	All	All	+0.448	<.001	7	view →
UCEC	All	All	−1.722	<.001	6	view →
BRCA	All	II,III,IV	−0.469	<.001	6	view →
ESCA	All	All	+1.012	.001	4	view →
KIRC	All	All	+0.318	<.001	4	view →
COAD	All	II,III,IV	−0.307	.039	3	view →
CHOL	All	All	+1.012	<.001	2	view →
READ	Female	All	−0.998	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TMEM35B–HNSC

Open the HNSC breakdown →