TMEM35B

Across TCGA patient cohorts, TMEM35B mutation is significantly associated with the RNA expression of many other genes, with 188 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM35B-associated genes across cancer lineages are NFYCP1, RNA5SP208, and MIR3912. Each is linked with TMEM35B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM35B-to-partner and partner-to-TMEM35B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFYCP1 grouped by TMEM35B-low versus TMEM35B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM35B→partner) and Y-score (partner→TMEM35B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFYCP1 →	+0.077	+2.563	<.001	.005	3	2
UCEC	RNA5SP208 →	+1.032	+3.420	<.001	.001	3	2
UCEC	MIR3912 →	+0.352	+3.152	<.001	<.001	3	1
UCEC	MIR3193 →	+0.547	+2.352	.001	.009	3	1
UCEC	MIR4484 →	+0.344	+2.801	<.001	.005	3	1
UCEC	MIR4510 →	+0.246	+3.868	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 188 associations by consensus.

NFYCP1 by TMEM35B expression — UCEC

Explore this box plot interactively →