TMEM35B

Across TCGA patient cohorts, TMEM35B mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM35B-associated genes across cancer lineages are Ku80, PREX1, and AMPK_pT172. Each is linked with TMEM35B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM35B-to-partner and partner-to-TMEM35B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TMEM35B-low versus TMEM35B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM35B→partner) and Y-score (partner→TMEM35B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.277	+2.820	.043	.035	3	1
UCEC	PREX1 →	-0.346	-3.000	.029	.037	3	1
UCEC	AMPK_pT172 →	+0.486	+3.013	.041	.019	3	1
UCEC	Annexin_VII →	-0.175	-3.000	.029	.037	3	1
UCEC	Di-Ras3 →	-0.199	-3.000	.020	.037	3	1
UCEC	MEK1 →	+0.527	+3.000	.012	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by TMEM35B expression — UCEC

Explore this box plot interactively →