TMEM35B

Across TCGA cell cohorts, TMEM35B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,434 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TMEM35B-associated GO terms across cancer lineages are Interleukin-10-mediated signaling pathway, Cortisol metabolic process, and CD8-positive, alpha-beta T cell activation. Each is linked with TMEM35B in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM35B-to-partner and partner-to-TMEM35B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interleukin-10-mediated signaling pathway grouped by TMEM35B-low versus TMEM35B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM35B→partner) and Y-score (partner→TMEM35B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Interleukin-10-mediated signaling pathway →	+0.229	+1.123	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Cortisol metabolic process →	-1.476	-1.386	<.001	.001	3	9
BREAST	CD8-positive, alpha-beta T cell activation →	+0.128	+1.772	<.001	<.001	3	9
BREAST	Negative regulation of immune response →	+0.107	+1.743	<.001	<.001	3	9
BREAST	Regulation of viral process →	+0.087	+1.432	.001	.002	3	9
BONE	Positive regulation of chemotaxis →	+0.144	+1.410	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,434 associations by consensus.

Interleukin-10-mediated signaling pathway by TMEM35B expression — BONE

Explore this box plot interactively →