TMEM35A

Across TCGA pan-cancer cohorts, TMEM35A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM35A data layer compared with 30 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM35A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM35A expression acts as an unfavorable survival marker.

UCEC, OV, and LUAD are the cancer types where TMEM35A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.443	0.942	.003	36	view →
OV	DFS	Median	All	0.453	0.923	.027	16	view →
LUAD	DFS	Median	II,III,IV	0.741	1.000	.006	11	view →
LSCC	OS	Median	All	0.932	1.000	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM35A–UCEC (DFS)

Open the UCEC breakdown →