TMEM31

Across TCGA patient cohorts, TMEM31 mutation is significantly associated with the RNA expression of many other genes, with 1,278 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM31-associated genes across cancer lineages are RNU6-666P, MTATP6P30, and RPS3AP17. Each is linked with TMEM31 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM31-to-partner and partner-to-TMEM31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-666P grouped by TMEM31-low versus TMEM31-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM31→partner) and Y-score (partner→TMEM31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-666P →	+0.438	+7.954	<.001	.008	3	2
COAD	MTATP6P30 →	+0.147	+7.741	<.001	.009	3	2
UCEC	RPS3AP17 →	+0.063	+2.455	.006	.001	3	2
LUSC	USP9YP10 →	+0.089	+7.924	<.001	.008	3	2
HNSC	OR10R2 →	+0.059	+7.954	<.001	.008	3	1
HNSC	RNU6-386P →	+0.438	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,278 associations by consensus.

RNU6-666P by TMEM31 expression — HNSC

Explore this box plot interactively →