TMEM30B

Across TCGA patient cohorts, TMEM30B mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM30B-associated genes across cancer lineages are CNTNAP3P5, NPBWR2, and OR7G3. Each is linked with TMEM30B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM30B-to-partner and partner-to-TMEM30B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTNAP3P5 grouped by TMEM30B-low versus TMEM30B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM30B→partner) and Y-score (partner→TMEM30B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CNTNAP3P5 →	+0.039	+5.306	<.001	.006	3	2
CESC	NPBWR2 →	+0.029	+5.010	.001	.009	3	1
CESC	OR7G3 →	+0.055	+5.669	.007	.003	3	1
CESC	RNU1-17P →	+0.378	+5.103	<.001	.008	3	1
CESC	RNU6-1066P →	+0.344	+5.418	.002	.005	3	1
CESC	RNU6-128P →	+0.347	+5.306	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

CNTNAP3P5 by TMEM30B expression — CESC

Explore this box plot interactively →