TMEM30A

Across TCGA patient cohorts, TMEM30A mutation is significantly associated with the RNA expression of many other genes, with 1,240 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM30A-associated genes across cancer lineages are MIR3978, RN7SKP221, and TRBV23OR9-2. Each is linked with TMEM30A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM30A-to-partner and partner-to-TMEM30A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3978 grouped by TMEM30A-low versus TMEM30A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM30A→partner) and Y-score (partner→TMEM30A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3978 →	+0.247	+5.080	<.001	.004	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
CESC	TRBV23OR9-2 →	+0.119	+5.539	<.001	.004	3	2
UCEC	RNA5SP86 →	+0.575	+2.534	<.001	.002	3	2
UCEC	RNA5SP198 →	+0.300	+2.451	.001	.007	3	2
UCEC	RNU2-47P →	+0.066	+3.738	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,240 associations by consensus.

MIR3978 by TMEM30A expression — SKCM

Explore this box plot interactively →