TMEM30A

Across TCGA pan-cancer cohorts, TMEM30A RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TMEM30A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM30A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM30A is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KICH, and LUSC are the cancer types where TMEM30A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM30A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.121	<.001	12	view →
KICH	All	All	−0.772	<.001	6	view →
LUSC	Male	All	−0.349	<.001	4	view →
BLCA	All	IV	+0.671	.004	3	view →
ESCA	All	All	+0.546	.002	3	view →
STAD	All	II,III,IV	+0.520	.018	3	view →
CHOL	All	II,III,IV	+1.309	.004	2	view →
KIRP	Male	All	−0.295	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TMEM30A–HNSC

Open the HNSC breakdown →